Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 5/20 | 0.35 |
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18949052 | 0.86 | SYK (0.40) | KCNH2NOS1NOS2TSHR | |
| SCHEMBL9974287 | 0.85 | KCNH2 (0.47) | KCNH2CTSSCTSKNOS1NOS2 | |
| SCHEMBL15318642 | 0.85 | TSHR (0.35) | KCNH2NOS1NOS2TSHRCXCR4 | |
| SCHEMBL10147431 | 0.83 | KCNH2 (0.46) | KCNH2CTSSCTSKNOS1NOS2 | |
| SCHEMBL3631871 | 0.82 | TSHR (0.41) | KCNH2TSHRALDH1A1GAAHPGD | |
| SCHEMBL15316714 | 0.81 | GABRA1 (0.34) | KCNH2CTSSCTSKNOS1NOS2 | |
| SCHEMBL20436438 | 0.81 | TSHR (0.37) | KCNH2TSHR | |
| SCHEMBL21117196 | 0.79 | MEN1 (0.35) | KCNH2TSHRALDH1A1 | |
| SCHEMBL8297334 | 0.79 | HTT (0.43) | NOS2TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL22298877 | 0.79 | HTT (0.43) | NOS2TSHRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082689-A1 | SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-06-21 | — | — | WO | disclosed |