Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 14/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | YES1 | P07947 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4352542 | 0.90 | MAPK1 (0.56) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL9972560 | 0.85 | MAPK1 (0.62) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4349173 | 0.85 | MAPK1 (0.61) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4345999 | 0.84 | MAPK1 (0.63) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4353911 | 0.84 | MAPK1 (0.57) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4352478 | 0.83 | MAPK1 (0.59) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4358644 | 0.80 | MAPK1 (0.68) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4345431 | 0.80 | MAPK1 (0.56) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4341383 | 0.79 | MAPK1 (0.58) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4346391 | 0.79 | MAPK1 (0.56) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202883-B2 | Substituted pyrido[2,3-b]pyrazine compounds as modulators of tyrosine kinases | AETERNA ZENTARIS GMBH (DE) | 2012-06-19 | — | — | US | disclosed |
| US-20090275534-A1 | NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF | ZENTARIS GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275534-A1 | NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF | PNPO, PDXK, MKI67 | MAPK1 460/4885PIK3CA 537/4885MAPK8 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.