⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853642 | 0.75 | — | — | |
| SCHEMBL6960389 | 0.73 | RAB9A (0.41) | — | |
| SCHEMBL9944268 | 0.73 | RAB9A (0.41) | — | |
| SCHEMBL6980533 | 0.72 | — | — | |
| SCHEMBL12476176 | 0.72 | — | — | |
| Bromide SCHEMBL1819096 | 0.72 | POLB (0.40) | — | |
| SCHEMBL9975308 | 0.70 | RAB9A (0.42) | — | |
| SCHEMBL3535851 | 0.69 | — | — | |
| SCHEMBL8636567 | 0.69 | POLB (0.38) | — | |
| SCHEMBL657078 | 0.69 | POLB (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345713-B2 | Compounds as modulators of TLR2 signaling | NEUROPORE THERAPIES, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210024539-A1 | COMPOUNDS AS MODULATORS OF TLR2 SIGNALING | NEUROPORE THERAPIES, INC. (US) | 2021-01-28 | — | — | US | disclosed |
| WO-2020198368-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING | NEUROPORE THERAPIES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| US-8772290-B2 | Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same | Oscotech Inc. (KR) | 2014-07-08 | — | — | US | disclosed |
| EP-1854789-B1 | QUINAZOLINE DERIVATIVE HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2013-10-09 | — | — | EP | disclosed |
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| WO-2010102673-A1 | HELLEBRIN AND HELLEBRIGENIN DERIVATIVES | UNIBIOSCREEN S.A. (BE) | 2010-09-16 | — | — | WO | disclosed |
| CN-101495450-A | Isoindole derivatives useful for treating pain, gastrointestinal diseases and cancer | ASTRAZENECA AB (SE) | 2009-07-29 | — | — | CN | disclosed |
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | SHIONOGI & CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |