Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380640 | 0.84 | MAPT (0.54) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL6979144 | 0.84 | APP (0.44) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL9975350 | 0.84 | NR1H4 (0.45) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL6960956 | 0.84 | MAPT (0.51) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL21340517 | 0.81 | MAPT (0.59) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL9812484 | 0.74 | NR4A2 (0.69) | MAPTMAOBNR4A2TP53GAA | |
| SCHEMBL38658158 | 0.74 | NR4A2 (0.57) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL22874574 | 0.72 | PNLIP (0.55) | POLB | |
| SCHEMBL11381972 | 0.72 | POLB (0.50) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 | |
| SCHEMBL11386536 | 0.72 | GCGR (0.58) | MAPTSMN1; SMN2ALDH1A1NCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | SHIONOGI & CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | ERBB2, EGFR, ABL1 | MAPT 4100/4885SMN1; SMN2 4182/4885ALDH1A1 4593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.