SCHEMBL9975419

SCHEMBL9975419

c1ccc(Nc2ccc(-c3cc4cc(Nc5ccccc5)ccc4o3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.54
APP P05067 4/20 0.51
ALDH1A1 P00352 4/20 0.50
HSD17B10 Q99714 2/20 0.50
CYP3A4 P08684 1/20 0.50
HPGD P15428 1/20 0.50
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
KDM4E B2RXH2 1/20 0.49
NFKB1 P19838 1/20 0.49
NPY1R P25929 1/20 0.49
NFKB2 Q00653 1/20 0.49
RELA Q04206 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
ESR1 P03372 1/20 0.49
ESR2 Q92731 1/20 0.49
FFAR1 O14842 1/20 0.44
AR P10275 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19683684 0.88 MAOB (0.62) MAOBAPPALDH1A1HSD17B10CYP3A4
SCHEMBL14900925 0.85 MAOB (0.51) MAOBAPPALDH1A1CYP3A4HPGD
SCHEMBL29706086 0.84 ALDH1A1 (0.57) MAOBALDH1A1HSD17B10CYP3A4HPGD
SCHEMBL29705905 0.84 ALDH1A1 (0.57) MAOBALDH1A1HSD17B10CYP3A4HPGD
SCHEMBL20196490 0.84 ALDH1A1 (0.57) MAOBALDH1A1HSD17B10CYP3A4HPGD
SCHEMBL20208852 0.84 MAOB (0.66) MAOBAPPALDH1A1MEN1KMT2A
SCHEMBL20208811 0.83 MAOB (0.60) MAOBAPPALDH1A1CYP3A4HPGD
SCHEMBL20209143 0.83 ALDH1A1 (0.53) MAOBALDH1A1HSD17B10CYP3A4HPGD
SCHEMBL28702769 0.80 APP (0.63) MAOBAPPALDH1A1HSD17B10CYP3A4
SCHEMBL24227094 0.79 ALDH1A1 (0.43) MAOBAPPALDH1A1HSD17B10CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546049-B2 Electrophotographic photoconductor and image forming apparatus using the same SHARP KABUSHIKI KAISHA (JP) 2013-10-01 US disclosed
US-20120156600-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND IMAGE FORMING APPARATUS USING THE SAME SHARP KABUSHIKI KAISHA (JP) 2012-06-21 US disclosed