Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.53 |
| ▸ | MMP13 | P45452 | 9/20 | 0.53 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | MMP7 | P09237 | 2/20 | 0.53 |
| ▸ | MMP1 | P03956 | 5/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14245113 | 0.91 | ADAM17 (0.52) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL995893 | 0.82 | ADAM17 (0.61) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL14245046 | 0.79 | ADAM17 (0.60) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL995892 | 0.79 | ADAM17 (0.36) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL10276954 | 0.78 | ADAM17 (0.61) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL16460281 | 0.76 | ADAM17 (0.50) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL14244962 | 0.76 | ADAM17 (0.60) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL996097 | 0.75 | ADAM17 (0.75) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL14245112 | 0.74 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP1MMP9 | |
| SCHEMBL6508472 | 0.73 | ADAM17 (0.76) | ADAM17MMP13MMP2MMP8MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2801568-A1 | Benzene-sulphonamide compounds, method for synthesising and use in medicine and in cosmetics | Galderma Research & Development (FR) | 2014-11-12 | — | — | EP | disclosed |
| EP-2448920-B1 | Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine | GALDERMA RES & DEV (FR) | 2014-08-13 | — | — | EP | disclosed |
| EP-2448920-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | Galderma Research & Development (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001089-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-06 | — | — | WO | disclosed |