Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 14/20 | 0.53 |
| ▸ | GSK3B | P49841 | 14/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.53 |
| ▸ | JAK2 | O60674 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.53 |
| ▸ | PLK1 | P53350 | 7/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.53 |
| ▸ | FLT3 | P36888 | 12/20 | 0.50 |
| ▸ | SRC | P12931 | 6/20 | 0.50 |
| ▸ | PRKACA | P17612 | 5/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977702 | 0.87 | GSK3A (0.55) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL15400465 | 0.87 | GSK3A (0.55) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL15400464 | 0.87 | GSK3A (0.55) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL15400279 | 0.87 | GSK3A (0.55) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL15400283 | 0.87 | GSK3A (0.55) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL16199017 | 0.83 | GSK3A (0.61) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL16199032 | 0.83 | GSK3A (0.61) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL16199088 | 0.83 | GSK3A (0.61) | GSK3AGSK3BPIK3CGJAK2PIK3CD | |
| SCHEMBL16199091 | 0.82 | GSK3A (0.72) | GSK3AGSK3BJAK2FLT3SRC | |
| SCHEMBL9977673 | 0.82 | GSK3A (0.72) | GSK3AGSK3BJAK2FLT3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083117-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |