Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4811491 | 0.82 | HTT (0.61) | HTTPOLBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL19159608 | 0.82 | HTT (0.61) | HTTPOLBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4811500 | 0.82 | HTT (0.61) | HTTPOLBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL18389936 | 0.79 | ALDH1A1 (0.48) | HTTDPP4DPP7POLBHSD17B10 | |
| SCHEMBL23062906 | 0.78 | HTT (0.70) | HTTPOLBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL18704960 | 0.77 | EPHX2 (0.45) | HTTDPP4DPP7POLBALDH1A1 | |
| SCHEMBL27979494 | 0.77 | HTT (0.88) | HTTPOLBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL20023236 | 0.76 | DPP4 (0.45) | HTTDPP4DPP7POLBHSD17B10 | |
| SCHEMBL20328020 | 0.76 | EPHX2 (0.44) | HTTDPP4DPP7POLBHSD17B10 | |
| SCHEMBL18713060 | 0.76 | EPHX2 (0.46) | HTTDPP4DPP7POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141252-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Inc. (US) | 2017-03-15 | — | — | EP | disclosed |
| WO-2012083117-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |