Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978172 | 0.88 | POLB (0.56) | POLBCYP2C19CYP2D6SIGMAR1CNR2 | |
| SCHEMBL15647059 | 0.85 | MEN1 (0.49) | CYP3A4CYP2C19CYP2D6CNR2MMP8 | |
| SCHEMBL5019854 | 0.83 | CNR2 (0.51) | POLBCYP3A4CYP2C19CYP2D6TP53 | |
| SCHEMBL15646163 | 0.83 | LMNA (0.53) | CYP3A4CYP2C19CYP2D6CYP1A2CNR2 | |
| SCHEMBL15646151 | 0.83 | CNR2 (0.51) | POLBCYP3A4CYP2C19CYP2D6CNR2 | |
| SCHEMBL14241873 | 0.82 | CNR2 (0.46) | CYP3A4CYP2C19CYP2D6CNR2MMP8 | |
| SCHEMBL15645772 | 0.81 | CNR2 (0.54) | POLBCYP3A4CYP2C19CYP2D6TP53 | |
| SCHEMBL12541931 | 0.81 | CNR2 (0.50) | CYP3A4CYP2C19CYP2D6CNR2MMP8 | |
| SCHEMBL14242693 | 0.80 | CNR2 (0.48) | POLBCYP3A4CYP2C19CYP2D6CNR2 | |
| SCHEMBL15646405 | 0.80 | NAMPT (0.51) | CYP3A4CYP2C19CYP2D6CNR2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |