Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | POLA1 | P09884 | 1/20 | 0.57 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | OSBP | P22059 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | UGCG | Q16739 | 2/20 | 0.52 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.49 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830883 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL31701636 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL9978568 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL12207653 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL2830884 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL9978647 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL5260401 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL9978599 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL2832560 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 | |
| SCHEMBL31700942 | 1.00 | DPP4 (0.76) | DPP4POLBPOLA1CYP46A1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105547-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-04-19 | — | — | US | claimed |
| US-9657046-B2 | Methods for the treatment and prevention of inflammatory diseases | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-05-23 | — | — | US | claimed |
| US-20140301996-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | UNIVERSITY OF BIRMINGHAM (GB) | 2014-10-09 | — | — | US | claimed |
| EP-2575824-A2 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | Children's Medical Center Corporation (US) | 2013-04-10 | — | — | EP | claimed |
| WO-2011149881-A2 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2011-12-01 | — | — | WO | claimed |
| US-20180105547-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-04-19 | — | — | US | disclosed |
| US-9657046-B2 | Methods for the treatment and prevention of inflammatory diseases | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-05-23 | — | — | US | disclosed |
| US-20140301996-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | UNIVERSITY OF BIRMINGHAM (GB) | 2014-10-09 | — | — | US | disclosed |
| EP-2575824-A2 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | Children's Medical Center Corporation (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149881-A2 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105547-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | ICOS, HRH2, HRH4 | DPP4 3689/4885POLB 4563/4885POLA1 4389/4885 |
| US-20140301996-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES | ICOS, HRH2, HRH4 | DPP4 3703/4885POLB 4524/4885POLA1 4366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.