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SCHEMBL9978705

SCHEMBL9978705

CCN1CCC(Oc2ccc(C(=O)Nc3ccc(CC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1

nearest known ligand 0.83

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FLT3 P36888 17/20 0.83
▸ CSF1R P07333 16/20 0.83
▸ PDGFRB P09619 4/20 0.83
▸ KIT P10721 4/20 0.83
▸ PDGFRA P16234 4/20 0.83
▸ LMNA P02545 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ RET P07949 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9978679 0.97 FLT3 (0.78) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL9978708 0.95 FLT3 (0.75) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL12065999 0.93 CSF1R (0.72) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL12067857 0.93 CSF1R (0.71) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL9978587 0.92 FLT3 (0.70) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL9978872 0.92 FLT3 (0.83) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL9978768 0.92 FLT3 (0.81) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL9979112 0.91 FLT3 (0.81) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL1698611 0.91 FLT3 (1.00) FLT3CSF1RPDGFRBKITPDGFRA
SCHEMBL9978770 0.90 FLT3 (0.83) FLT3CSF1RPDGFRBKITPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011150201-A2 AZOLYL AMIDE COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATION (US) 2011-12-01 — — WO disclosed