Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450832 | 0.94 | CYP3A4 (0.58) | CYP3A4CYP2C9GAASMN1; SMN2LMNA | |
| SCHEMBL1682185 | 0.93 | CYP3A4 (0.60) | CYP3A4CYP2C9GAASMN1; SMN2LMNA | |
| SCHEMBL15261862 | 0.90 | CYP3A4 (0.55) | CYP3A4CYP2C9GAASMN1; SMN2LMNA | |
| SCHEMBL13003217 | 0.84 | ALDH1A1 (0.46) | CYP3A4CYP2C9GAASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL27578134 | 0.84 | CYP3A4 (0.57) | CYP3A4CYP2C9HDAC8HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL27558225 | 0.84 | CYP3A4 (0.57) | CYP3A4CYP2C9HDAC8HDAC3HDAC1 | |
| SCHEMBL11857227 | 0.82 | CYP3A4 (0.66) | CYP3A4CYP2C9GAASMN1; SMN2LMNA | |
| SCHEMBL11854037 | 0.82 | CYP3A4 (0.66) | CYP3A4CYP2C9GAASMN1; SMN2LMNA | |
| SCHEMBL14401197 | 0.82 | ALDH1A1 (0.44) | CYP3A4CYP2C9SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL12713132 | 0.82 | ALDH1A1 (0.44) | CYP3A4CYP2C9GAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576515-B1 | Pyrazolecarboxamide derivatives and their use as microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-16 | — | — | EP | disclosed |
| US-8552049-B2 | Pyrazolecarboxamide derivatives and their use as microbiocides | Syngenta Corp Protection, LLC (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2576515-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | Syngenta Participations AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2011147690-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-01 | — | — | WO | disclosed |
| US-4237158-A | FOR PLANT DISEASES; PLANT GROWTH REGULATORS | ROHM AND HAAS COMPANY (US) | 1980-12-02 | — | — | US | disclosed |
| US-4118461-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1978-10-03 | — | — | US | disclosed |
| US-4115578-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4105762-A | Metal salt complexes of 1-substituted aralkyl imidazoles, and methods and compositions for controlling phytopathogenic fungi using them | ROHM AND HAAS COMPANY (US) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | HRH4, MRGPRX4, C3AR1 | CYP3A4 361/4885CYP2C9 743/4885GAA 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.