Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.60 |
| ▸ | APP | P05067 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LATS1 | O95835 | 11/20 | 0.48 |
| ▸ | LATS2 | Q9NRM7 | 10/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | PRKCH | P24723 | 2/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12039899 | 0.89 | PDE5A (0.54) | PDE5AAPPEGFRLATS1LATS2 | |
| SCHEMBL17933800 | 0.77 | SGK1 (0.51) | PDE5AAPPPDE2ALMNAROCK2 | |
| SCHEMBL27253658 | 0.76 | HTT (0.62) | PDE5AAPPEGFRALDH1A1MAPK1 | |
| SCHEMBL31620265 | 0.76 | HTT (0.62) | PDE5AAPPEGFRALDH1A1MAPK1 | |
| SCHEMBL31572126 | 0.75 | PDE2A (0.46) | PDE5AAPPPDE2AMEN1KMT2A | |
| SCHEMBL20119397 | 0.75 | PDE5A (0.48) | PDE5AAPPPTGS1TBXAS1PTGS2 | |
| SCHEMBL29833956 | 0.75 | PDE5A (0.48) | PDE5AAPPPTGS1TBXAS1PTGS2 | |
| SCHEMBL29388255 | 0.75 | APP (1.00) | PDE5AAPPEGFRPTGS1TBXAS1 | |
| SCHEMBL3113122 | 0.75 | APP (1.00) | PDE5AAPPEGFRPTGS1TBXAS1 | |
| SCHEMBL23498518 | 0.74 | PDE4A (0.64) | PDE5AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | PDE5A, PDE12, PDE7B | PDE5A 1/4885APP 4457/4885EGFR 4831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.