Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 17/20 | 0.61 |
| ▸ | LATS2 | Q9NRM7 | 11/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PRKCH | P24723 | 1/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12039897 | 0.88 | CYP1A2 (0.55) | LATS1LATS2LMNAALDH1A1MAPK1 | |
| SCHEMBL12039884 | 0.88 | LATS1 (0.61) | LATS1LATS2LMNAALDH1A1HPGD | |
| SCHEMBL9979316 | 0.85 | CYP1A2 (0.54) | LATS1LATS2LMNAALDH1A1MAPK1 | |
| SCHEMBL9979400 | 0.78 | CYP1A2 (0.48) | LATS1LATS2LMNAALDH1A1MAPK1 | |
| SCHEMBL20574643 | 0.77 | LATS1 (1.00) | LATS1LATS2LMNAALDH1A1HPGD | |
| SCHEMBL29650626 | 0.77 | LATS1 (1.00) | LATS1LATS2LMNAALDH1A1HPGD | |
| SCHEMBL9979110 | 0.76 | CYP1A2 (0.52) | LATS1LATS2LMNAALDH1A1MAPK1 | |
| SCHEMBL14475071 | 0.71 | CYP1A2 (0.58) | LMNAALDH1A1HPGDMAPK1MEN1 | |
| SCHEMBL12058167 | 0.69 | GBA1 (0.41) | LATS1LATS2LMNAALDH1A1MAPK1 | |
| SCHEMBL9979050 | 0.69 | GBA1 (0.42) | LATS1LATS2LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | claimed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | PDE5A, PDE12, PDE7B | LATS1 4435/4885LATS2 4167/4885LMNA 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.