SCHEMBL9979676

SCHEMBL9979676

COOC[C@@H]1COc2cc(O)ccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.40
TMEM97 Q5BJF2 2/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
PPARG P37231 4/20 0.38
PPARD Q03181 4/20 0.38
FFAR1 O14842 2/20 0.38
HTR2B P41595 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
THRB P10828 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
ESR1 P03372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29288527 0.80 TMEM97 (0.41) CYP3A4TMEM97MAOAMAOBPPARG
SCHEMBL16448789 0.80 CYP3A4 (0.44) CYP3A4TMEM97MAOAMAOBHTR2B
SCHEMBL9749071 0.80 CYP3A4 (0.44) CYP3A4TMEM97MAOAMAOBHTR2B
SCHEMBL28073790 0.78 FFAR1 (0.42) CYP3A4TMEM97MAOAMAOBPPARG
SCHEMBL16448786 0.78 FFAR1 (0.42) CYP3A4TMEM97MAOAMAOBPPARG
SCHEMBL435248 0.77 FFAR1 (0.53) PPARGPPARDFFAR1
SCHEMBL9277990 0.77 FFAR1 (0.53) PPARGPPARDFFAR1
SCHEMBL9275740 0.77 FFAR1 (0.53) PPARGPPARDFFAR1
SCHEMBL18630107 0.77 CYP3A4 (0.43) CYP3A4TMEM97MAOAMAOBKDM4E
SCHEMBL15153586 0.76 CYP3A4 (0.44) CYP3A4TMEM97MAOAMAOBPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012081570-A1 LACTAM COMPOUND OR A SALT THEREOF, AND PPAR ACTIVATOR あすか製薬株式会社 (JP) 2012-06-21 WO disclosed