Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941441 | 0.82 | EPHX2 (1.00) | EPHX2PTGS2ALOX5PTGS1 | |
| SCHEMBL15460590 | 0.79 | EPHX2 (0.89) | EPHX2PTGS2ALOX5PTGS1 | |
| SCHEMBL9938490 | 0.78 | EPHX2 (1.00) | EPHX2PTGS2ALOX5PTGS1 | |
| SCHEMBL15460594 | 0.78 | EPHX2 (0.86) | EPHX2PTGS2ALOX5PTGS1 | |
| SCHEMBL9938515 | 0.78 | EPHX2 (1.00) | EPHX2PTGS2ALOX5PTGS1MALT1 | |
| SCHEMBL9941597 | 0.76 | EPHX2 (1.00) | EPHX2PTGS2ALOX5PTGS1 | |
| SCHEMBL9941289 | 0.75 | PTGS2 (1.00) | EPHX2PTGS2ALOX5PTGS1CA1 | |
| SCHEMBL6345389 | 0.75 | CA9 (0.70) | EPHX2PTGS2PTGS1MALT1CA1 | |
| SCHEMBL9939025 | 0.75 | EPHX2 (1.00) | EPHX2PTGS2ALOX5PTGS1 | |
| SCHEMBL15463053 | 0.75 | PTGS2 (0.80) | EPHX2PTGS2ALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082647-A2 | PYRAZOLE INHIBITORS OF COX-2 AND sEH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-06-21 | — | — | WO | disclosed |