Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10177451 | 0.87 | HPGDS (0.38) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL204798 | 0.87 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14CDC7 | |
| SCHEMBL2706498 | 0.87 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14CDC7 | |
| Hydrochloric Acid SCHEMBL12098609 | 0.86 | MAPK13 (0.45) | MAPK13MAPK12MAPK11MAPK14CDC7 | |
| Hydrochloric Acid SCHEMBL12098612 | 0.86 | MAPK13 (0.45) | MAPK13MAPK12MAPK11MAPK14CDC7 | |
| SCHEMBL933682 | 0.85 | HPGDS (0.37) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL7604946 | 0.83 | HPGDS (0.43) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL15373033 | 0.83 | HPGDS (0.35) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL10144865 | 0.83 | HPGDS (0.35) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL12661252 | 0.83 | MAPK13 (0.43) | MAPK13MAPK12MAPK11MAPK14CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575475-A1 | INHIBITORS OF HCV NS5A | Presidio Pharmaceuticals, Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011150243-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2011-12-01 | — | — | WO | disclosed |