Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.64 |
| ▸ | CSF1R | P07333 | 12/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | KIT | P10721 | 3/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.64 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978910 | 0.95 | CSF1R (0.61) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL9978582 | 0.93 | FLT3 (0.66) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698764 | 0.90 | FLT3 (0.75) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL9980487 | 0.87 | FLT3 (0.81) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698962 | 0.87 | FLT3 (0.71) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL9978552 | 0.86 | CSF1R (0.59) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698846 | 0.86 | FLT3 (0.72) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL9978942 | 0.85 | CSF1R (0.66) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL12067859 | 0.85 | FLT3 (0.62) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL9978609 | 0.85 | CSF1R (0.65) | FLT3CSF1RPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011150201-A2 | AZOLYL AMIDE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | claimed |
| WO-2011150201-A2 | AZOLYL AMIDE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |