Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PMM2 | O15305 | 2/20 | 0.33 |
| ▸ | MPI | P34949 | 2/20 | 0.33 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29709471 | 0.78 | BTK (0.50) | BTKJAK2TDO2IDO1HCAR1 | |
| SCHEMBL149181 | 0.78 | BTK (0.50) | BTKJAK2TDO2IDO1HCAR1 | |
| SCHEMBL12070562 | 0.76 | BTK (0.50) | BTKJAK2TDO2IDO1PMM2 | |
| SCHEMBL148828 | 0.73 | JAK2 (0.49) | BTKJAK2TDO2IDO1 | |
| SCHEMBL16320311 | 0.70 | BTK (0.68) | BTKJAK2TDO2IDO1PMM2 | |
| SCHEMBL16320335 | 0.70 | BTK (0.68) | BTKJAK2TDO2IDO1PMM2 | |
| SCHEMBL148493 | 0.69 | BTK (0.46) | BTKJAK2TDO2IDO1 | |
| SCHEMBL144722 | 0.69 | BTK (0.49) | BTKJAK2TDO2IDO1 | |
| SCHEMBL29709488 | 0.69 | BTK (0.49) | BTKJAK2TDO2IDO1 | |
| SCHEMBL14860170 | 0.69 | JAK2 (0.61) | BTKJAK2TDO2IDO1IDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582668-A1 | CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011159857-A1 | CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-22 | — | — | WO | disclosed |