SCHEMBL998528

SCHEMBL998528

C#CCCCCNCCCNCCC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SAT1 P21673 1/20 0.50
TSHR P16473 2/20 0.46
ALDH1A1 P00352 1/20 0.46
CYP2C19 P33261 2/20 0.44
CYP1A2 P05177 1/20 0.44
PAOX Q6QHF9 1/20 0.42
MEN1 O00255 1/20 0.40
GLA P06280 1/20 0.40
KMT2A Q03164 1/20 0.40
HRH4 Q9H3N8 2/20 0.33
HRH3 Q9Y5N1 2/20 0.33
RELA Q04206 4/20 0.33
KDM1A O60341 2/20 0.32
ADH1B P00325 1/20 0.32
ADH1A P07327 1/20 0.32
ADH7 P40394 1/20 0.32
S1PR2 O95136 3/20 0.31
S1PR4 O95977 3/20 0.31
S1PR1 P21453 3/20 0.31
S1PR3 Q99500 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1454742 0.98 TSHR (0.48) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL1452768 0.91
SCHEMBL664345 0.85 SAT1 (0.44) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL18758930 0.84 TSHR (0.62) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL8023168 0.81 SAT1 (0.67) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL1454733 0.80
SCHEMBL30744262 0.80 TSHR (0.69) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL7513630 0.80 TSHR (0.69) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL14543224 0.77 TSHR (0.59) SAT1TSHRALDH1A1CYP2C19CYP1A2
SCHEMBL663749 0.77 SAT1 (0.46) SAT1TSHRALDH1A1CYP2C19CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2453886-A2 PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE Pathologica, LLC. (US) 2012-05-23 EP disclosed
WO-2011009039-A2 PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE PATHOLOGICA LLC (US) 2011-01-20 WO disclosed