Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 14/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9985690 | 0.87 | TNNI3K (0.49) | TNNI3KBRAFMAPT | |
| SCHEMBL9986750 | 0.84 | TNNI3K (0.59) | TNNI3KBRAFMAPT | |
| SCHEMBL12065842 | 0.77 | TNNI3K (0.77) | TNNI3KBRAF | |
| SCHEMBL9980497 | 0.75 | SLC6A4 (0.45) | TNNI3KBRAFMAPTKDM4EGAA | |
| SCHEMBL9986093 | 0.73 | BRAF (0.41) | TNNI3KBRAFMAPTIDH2TEAD1 | |
| SCHEMBL9986375 | 0.73 | TNNI3K (0.57) | TNNI3KBRAF | |
| SCHEMBL9985681 | 0.71 | TNNI3K (0.56) | TNNI3KBRAF | |
| SCHEMBL9985725 | 0.71 | TNNI3K (0.57) | TNNI3KBRAFMAPT | |
| SCHEMBL9985530 | 0.70 | TNNI3K (0.61) | TNNI3KBRAFIDH2 | |
| SCHEMBL9986060 | 0.68 | TNNI3K (0.64) | TNNI3KBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | claimed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |