Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.59 |
| ▸ | JAK1 | P23458 | 6/20 | 0.59 |
| ▸ | TYK2 | P29597 | 4/20 | 0.59 |
| ▸ | JAK3 | P52333 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29080044 | 0.83 | JAK2 (0.55) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL13374857 | 0.81 | TMEM97 (0.49) | — | |
| SCHEMBL13490506 | 0.81 | JAK2 (0.55) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL7502653 | 0.81 | JAK2 (0.57) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL4513756 | 0.80 | JAK2 (0.54) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL29087342 | 0.80 | SMN1; SMN2 (0.59) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL29080164 | 0.80 | JAK2 (0.52) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL29806002 | 0.79 | USP30 (0.56) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL9986596 | 0.79 | USP30 (0.56) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL31603397 | 0.79 | PARP1 (0.49) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |