Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | BCL9 | O00512 | 7/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK1 | P23458 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31198901 | 0.91 | PDE4B (0.54) | SMN1; SMN2NPC1RAB9ABCL9CTNNB1 | |
| SCHEMBL16158890 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL18398622 | 0.87 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9ABCL9CTNNB1 | |
| SCHEMBL21138877 | 0.86 | ALDH1A1 (0.57) | SMN1; SMN2NPC1RAB9ABCL9CTNNB1 | |
| SCHEMBL4392358 | 0.86 | PRMT5 (0.56) | BCL9CTNNB1ALDH1A1CYP2C19POLB | |
| SCHEMBL2440282 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL6128832 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL5368396 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL19405234 | 0.85 | PDE4B (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL31198971 | 0.85 | PDE4B (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116806217-A | Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof | 拉帕塔疗法公司 | 2023-09-26 | — | — | CN | disclosed |