Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Telmisartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 6/20 | 0.98 |
| ▸ | PPARG | P37231 | 4/20 | 0.98 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.98 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | ACE | P12821 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.98 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.98 |
| ▸ | PDE4A | P27815 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Telmisartan SCHEMBL2122886 | 0.99 | AGTR1 (1.00) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL29691699 | 0.99 | AGTR1 (1.00) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL29414101 | 0.99 | AGTR1 (1.00) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL4464 | 0.99 | AGTR1 (1.00) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL29356790 | 0.99 | AGTR1 (1.00) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL972356 | 0.98 | AGTR1 (0.98) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL3384004 | 0.98 | AGTR1 (0.98) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL29113697 | 0.98 | AGTR1 (0.98) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL1071821 | 0.98 | AGTR1 (0.98) | AGTR1PPARGAGTR2KDM4EABCC3 | |
| Telmisartan SCHEMBL29032036 | 0.98 | AGTR1 (0.98) | AGTR1PPARGAGTR2KDM4EABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732509-A | Telmisartan ammonium salt crystal form and preparation method thereof | 浙江华海药业股份有限公司 | 2016-07-06 | — | — | CN | claimed |
| EP-2046756-A2 | PREPARATION OF TELMISARTAN SALTS | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2009-04-15 | — | — | EP | claimed |
| WO-2007147889-A2 | PREPARATION OF TELMISARTAN SALTS | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2007-12-27 | — | — | WO | claimed |
| CN-105732509-A | Telmisartan ammonium salt crystal form and preparation method thereof | 浙江华海药业股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105732509-A | Telmisartan ammonium salt crystal form and preparation method thereof | 浙江华海药业股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105732509-A | Telmisartan ammonium salt crystal form and preparation method thereof | 浙江华海药业股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103142596-B | Medicinal composition containing telmisartan and pitavastatin | UNIV SICHUAN | 2015-05-06 | — | — | CN | disclosed |
| CN-103142596-A | Medicinal composition containing telmisartan and pitavastatin | UNIV SICHUAN | 2013-06-12 | — | — | CN | disclosed |
| EP-2448575-A2 | PHARMACEUTICAL COMPOSITION INCREASING SOLUBILITY AND STABILITY | Mahmut, Bilgic (TR) | 2012-05-09 | — | — | EP | disclosed |
| EP-2448576-A2 | SOLUBILITY ENHANCING PHARMACEUTICAL COMPOSITION | Bilgic, Mahmut (TR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002423-A2 | SOLUBILITY ENHANCING PHARMACEUTICAL COMPOSITION | BILGIC MAHMUT (TR) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002425-A2 | PHARMACEUTICAL COMPOSITION INCREASING SOLUBILITY AND STABILITY | MAHMUT BILGIG (TR) | 2011-01-06 | — | — | WO | disclosed |
| EP-2046756-A2 | PREPARATION OF TELMISARTAN SALTS | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007147889-A2 | PREPARATION OF TELMISARTAN SALTS | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2007-12-27 | — | — | WO | disclosed |