Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986985 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL11029931 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL9986984 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL9986906 | 0.88 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL11031293 | 0.88 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL9986904 | 0.88 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL9986427 | 0.87 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL11885692 | 0.87 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL11885693 | 0.87 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL9986498 | 0.87 | HSD11B1 (1.00) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585444-A1 | AZASPIROHEXANONES AS INHIBITORS OF 11-BETA-HSD1 FOR THE TREATMENT OF METABOLIC DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011161128-A1 | AZASPIROHEXANONES AS INHIBITORS OF 11-BETA-HSD1 FOR THE TREATMENT OF METABOLIC DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-12-29 | — | — | WO | disclosed |