Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | USP14 | P54578 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9999291 | 0.86 | PIK3CD (0.41) | EGFRSRCPIK3CDPIK3R1PIK3CA | |
| SCHEMBL9987042 | 0.83 | TSHR (0.40) | KDM4EEGFRSRCTSHRLMNA | |
| SCHEMBL1075868 | 0.76 | KDM4E (0.42) | KDM4EEGFRSRCTSHRLMNA | |
| SCHEMBL1078159 | 0.74 | MAPT (0.46) | KDM4EEGFRSRCTSHRLMNA | |
| SCHEMBL23886687 | 0.72 | KDM4E (0.40) | KDM4ETSHRLMNAMAPTHTT | |
| SCHEMBL30176314 | 0.72 | KDM4E (0.40) | KDM4ETSHRLMNAMAPTHTT | |
| SCHEMBL9987968 | 0.71 | ALDH1A1 (0.49) | KDM4ELMNAMAPTHTTALDH1A1 | |
| SCHEMBL12387050 | 0.70 | MEN1 (0.43) | KDM4ETSHRLMNAMAPTHTT | |
| SCHEMBL23886832 | 0.70 | KDM4E (0.39) | KDM4ELMNAMAPTHTTPIK3CA | |
| SCHEMBL30176358 | 0.70 | KDM4E (0.39) | KDM4ELMNAMAPTHTTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163195-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |