Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984163 | 0.93 | MAPT (0.44) | JAK2BRD4MAPTMAPK1MALT1 | |
| SCHEMBL9984251 | 0.91 | MAPT (0.39) | KMT2AMAPTMEN1MAPK1MALT1 | |
| SCHEMBL9987422 | 0.91 | TDP1 (0.40) | TDP1SERPINE1JAK2BRD4KMT2A | |
| SCHEMBL9984367 | 0.90 | SYK (0.36) | BRD4KMT2AMAPTMEN1MAPK1 | |
| SCHEMBL9983856 | 0.88 | MAPT (0.39) | TDP1MAPTMAPK1POLBCYP2C9 | |
| SCHEMBL9984365 | 0.86 | MAPT (0.40) | MAPTMAPK1POLBGAA | |
| SCHEMBL9988236 | 0.86 | BCL2L2 (0.36) | TDP1JAK2BRD4KMT2AMAPT | |
| SCHEMBL9984312 | 0.86 | ALDH1A1 (0.41) | JAK2KMT2AMAPTMEN1SYK | |
| SCHEMBL9984255 | 0.83 | MAPT (0.38) | TDP1JAK2KMT2AMAPTMEN1 | |
| SCHEMBL9984717 | 0.82 | PLK1 (0.38) | KMT2AMAPTMEN1MAPK1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394993-A2 | NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Dong Wha Pharm. Co., Ltd. (KR) | 2011-12-14 | — | — | EP | disclosed |