Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.72 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987615 | 0.98 | GCK (0.73) | GCKACACBACACAGRM5 | |
| SCHEMBL9987471 | 0.96 | GCK (0.74) | GCK | |
| SCHEMBL9987558 | 0.89 | GCK (0.75) | GCKACACBGRM5 | |
| SCHEMBL9987186 | 0.88 | GCK (0.75) | GCKHRH1HRH3 | |
| SCHEMBL9987101 | 0.85 | GCK (0.96) | GCKGRM5 | |
| SCHEMBL12070280 | 0.84 | GCK (0.78) | GCK | |
| SCHEMBL9987113 | 0.84 | GCK (1.00) | GCK | |
| SCHEMBL9987418 | 0.83 | GCK (1.00) | GCKGRM5 | |
| SCHEMBL9987109 | 0.81 | GCK (0.82) | GCK | |
| SCHEMBL9987134 | 0.81 | GCK (0.93) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |