Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | AXL | P30530 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371811 | 0.87 | MET (0.64) | METKDRAXL | |
| SCHEMBL19711775 | 0.84 | MET (0.62) | METKDRAXL | |
| SCHEMBL371539 | 0.84 | MET (0.70) | METKDRAXLPDGFRA | |
| SCHEMBL12335707 | 0.84 | MET (0.70) | METKDRAXLPDGFRA | |
| SCHEMBL1484298 | 0.83 | MET (0.69) | METKDRPDGFRA | |
| SCHEMBL17867476 | 0.83 | MET (0.77) | METKDRAXLPDGFRA | |
| SCHEMBL373915 | 0.83 | MET (0.64) | METKDRAXL | |
| SCHEMBL372095 | 0.83 | MET (0.68) | METKDR | |
| SCHEMBL14970998 | 0.83 | MET (0.63) | METKDRAXLPDGFRA | |
| SCHEMBL1879811 | 0.83 | MET (0.78) | METKDRAXLPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392564-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |