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SCHEMBL9987290

SCHEMBL9987290

CNS(=O)(=O)c1ccc(Oc2cc(OC(C)C)cc(-c3ncc(C)c(=O)[nH]3)c2)cc1

nearest known ligand 0.81

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ GCK P35557 18/20 0.81
▸ LMNA P02545 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ FFAR4 Q5NUL3 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9987788 0.90 GCK (1.00) GCKLMNAHTTSMN1; SMN2
SCHEMBL9987993 0.90 GCK (1.00) GCKLMNAHTTSMN1; SMN2
SCHEMBL9986909 0.89 GCK (1.00) GCK
SCHEMBL9987956 0.84 GCK (1.00) GCKLMNAHTTSMN1; SMN2
SCHEMBL9986970 0.79 GCK (0.82) GCK
SCHEMBL9986967 0.79 GCK (0.82) GCK
SCHEMBL9986994 0.79 GCK (1.00) GCK
SCHEMBL9986847 0.78 GCK (0.80) GCK
SCHEMBL9986881 0.78 GCK (0.79) GCK
SCHEMBL9986842 0.78 GCK (0.80) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011158149-A1 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES PFIZER INC. (US) 2011-12-22 — — WO claimed
WO-2011158149-A1 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES PFIZER INC. (US) 2011-12-22 — — WO disclosed
WO-2011158149-A1 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES PFIZER INC. (US) 2011-12-22 — — WO disclosed