Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987788 | 1.00 | GCK (1.00) | GCKLMNAHTTSMN1; SMN2 | |
| SCHEMBL9986967 | 0.90 | GCK (0.82) | GCK | |
| SCHEMBL9986970 | 0.90 | GCK (0.82) | GCK | |
| SCHEMBL9987290 | 0.90 | GCK (0.81) | GCKLMNAHTTSMN1; SMN2 | |
| SCHEMBL9986847 | 0.89 | GCK (0.80) | GCK | |
| SCHEMBL9986842 | 0.89 | GCK (0.80) | GCK | |
| SCHEMBL9986944 | 0.88 | GCK (1.00) | GCK | |
| SCHEMBL9986947 | 0.88 | GCK (1.00) | GCK | |
| SCHEMBL9986918 | 0.86 | GCK (0.75) | GCK | |
| SCHEMBL9986915 | 0.86 | GCK (0.75) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | claimed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |