Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662599 | 0.85 | MGLL (0.53) | MGLLHPGDSERPINE1TSHR | |
| SCHEMBL12548117 | 0.81 | HPGD (0.74) | KDM4EHPGDALDH1A1HSD11B1GAA | |
| SCHEMBL7909422 | 0.81 | SMN1; SMN2 (0.53) | KDM4EHPGDALDH1A1HSD11B1SERPINE1 | |
| SCHEMBL12547696 | 0.77 | SMN1; SMN2 (0.57) | MGLLKDM4EHPGDALDH1A1HSD11B1 | |
| SCHEMBL12547973 | 0.77 | HPGD (0.69) | KDM4EHPGDALDH1A1HSD11B1SERPINE1 | |
| SCHEMBL7895741 | 0.77 | HPGD (0.50) | KDM4EHPGDALDH1A1HSD11B1GAA | |
| SCHEMBL1947109 | 0.75 | HPGD (0.65) | MGLLHPGDALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7906862 | 0.74 | HPGD (0.66) | MGLLHPGDALDH1A1GAASMN1; SMN2 | |
| SCHEMBL1424454 | 0.73 | HPGD (0.76) | MGLLKDM4EHPGDALDH1A1MAPK1 | |
| SCHEMBL2644377 | 0.73 | HPGD (0.67) | MGLLHPGDALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |