Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23149339 | 0.81 | — | — | |
| SCHEMBL19741751 | 0.78 | — | — | |
| SCHEMBL965286 | 0.78 | KMT2A (0.82) | KMT2AHTTLMNAPOLBALDH1A1 | |
| SCHEMBL5238596 | 0.77 | KMT2A (0.72) | KMT2AHTTPOLBKDM4EMAPK1 | |
| SCHEMBL966438 | 0.77 | KMT2A (0.78) | KMT2AHTTLMNAALDH1A1MAPK1 | |
| SCHEMBL4803949 | 0.77 | KMT2A (0.78) | KMT2AHTTLMNAALDH1A1MAPK1 | |
| SCHEMBL17273858 | 0.77 | KMT2A (0.78) | KMT2AHTTLMNAALDH1A1MAPK1 | |
| SCHEMBL29135819 | 0.76 | KMT2A (0.59) | KMT2AHTTLMNAKDM4EALDH1A1 | |
| SCHEMBL10644138 | 0.76 | BLM (0.40) | KMT2ALMNAALDH1A1TSHRMEN1 | |
| SCHEMBL512076 | 0.73 | L3MBTL1 (0.47) | KMT2APOLBALDH1A1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |