Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856186 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL3950479 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL11120122 | 0.86 | LMNA (0.50) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL1069568 | 0.85 | TSHR (0.46) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL1515381 | 0.83 | LMNA (0.57) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL1859157 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL3634052 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL574934 | 0.80 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL1713612 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL7838421 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |