Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30292447 | 0.81 | POLB (0.46) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| SCHEMBL9990166 | 0.81 | POLB (0.46) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| SCHEMBL17358815 | 0.79 | POLB (0.44) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| SCHEMBL15550676 | 0.74 | ALDH1A1 (0.49) | POLBSMN1; SMN2LMNAKDM4EALDH1A1 | |
| Ampyzine SCHEMBL122178 | 0.73 | POLB (0.50) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| Ampyzine SCHEMBL27512340 | 0.73 | POLB (0.50) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| SCHEMBL17258949 | 0.73 | HDAC6 (0.44) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| SCHEMBL1722970 | 0.73 | MAPT (0.39) | SMN1; SMN2KMT2AALDH1A1CYP2D6MEN1 | |
| SCHEMBL10394905 | 0.72 | POLB (0.63) | POLBHDAC6SMN1; SMN2LMNATP53 | |
| SCHEMBL27529146 | 0.72 | POLB (0.44) | POLBHDAC6SMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319379-A1 | Substituted Indazole Amides And Their Use As Glucokinase Activators | CORBETT JEFFREY W (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319379-A1 | Substituted Indazole Amides And Their Use As Glucokinase Activators | GCKR, GCK, GALK1 | POLB 4318/4885HDAC6 575/4885SMN1; SMN2 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.