Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.65 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.64 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.64 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.52 |
| ▸ | KDM5C | P41229 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KDM6B | O15054 | 3/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL6426584 | 1.00 | LMNA (0.65) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL8574919 | 0.97 | LMNA (0.61) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL28874138 | 0.89 | EGLN1 (0.69) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Alpha-Ketoglutaric Acid SCHEMBL1272323 | 0.88 | EGLN1 (0.78) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL15324711 | 0.88 | LMNA (0.52) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Glutarate SCHEMBL6833059 | 0.87 | SLC22A6 (0.69) | LMNASLC15A2OR51E2SLC22A6TSHR | |
| Alpha-Ketoglutaric Acid SCHEMBL2575988 | 0.86 | EGLN1 (0.74) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Alpha-Ketoglutaric Acid SCHEMBL6687849 | 0.86 | EGLN1 (0.74) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL28874136 | 0.86 | LMNA (0.65) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL35204 | 0.85 | EGLN1 (0.75) | LMNASLC15A2EGLN1ALKBH5SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110300595-A1 | MICROORGANISM FOR PRODUCING SUCCINIC ACID | ORGANO BALANCE GMBH (DE) | 2011-12-08 | — | — | US | disclosed |