Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 18/20 | 0.77 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797407 | 0.95 | S1PR1 (0.71) | S1PR1S1PR3 | |
| SCHEMBL17797404 | 0.91 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL17797406 | 0.89 | S1PR1 (0.60) | S1PR1S1PR3SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL17805162 | 0.88 | S1PR1 (0.62) | S1PR1S1PR3 | |
| SCHEMBL176871 | 0.87 | S1PR1 (1.00) | S1PR1S1PR3SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL9996208 | 0.84 | S1PR1 (0.86) | S1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL15497196 | 0.84 | S1PR1 (0.60) | S1PR1S1PR3SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL15499276 | 0.84 | S1PR1 (0.66) | S1PR1S1PR3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15397650 | 0.83 | S1PR1 (0.93) | S1PR1S1PR3SMN1; SMN2KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL9996181 | 0.83 | S1PR1 (0.91) | S1PR1S1PR3SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9707205-B2 | S1P receptors modulators and their use thereof | AKAAL PHARMA PTY LTD. (AU) | 2017-07-18 | — | — | US | claimed |
| US-20160038455-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | AKAAL PHARMA PTY LTD. (AU) | 2016-02-11 | — | — | US | claimed |
| US-9193716-B2 | S1P receptors modulators and their use thereof | AKAAL PHARMA PTY LTD. (AU) | 2015-11-24 | — | — | US | claimed |
| WO-2014063199-A1 | ORGANIC COMPOUNDS | AKAAL PHARMA PTY LTD (AU) | 2014-05-01 | — | — | WO | claimed |
| US-20140066427-A1 | S1P Receptors Modulators and Their Use Thereof | AKAAL PHARMA PTY LTD. (AU) | 2014-03-06 | — | — | US | claimed |
| US-8592399-B2 | S1P receptors modulators and their use thereof | AKAAL PHARMA PTY LTD. (AU) | 2013-11-26 | — | — | US | claimed |
| US-20110318388-A1 | S1P Receptors Modulators and Their Use Thereof | AKAAL PHARMA PTY LTD (AU) | 2011-12-29 | — | — | US | claimed |
| WO-2017024355-A1 | COMPOSITIONS COMPRISING S1P RECEPTOR MODULATORS | AKAAL PHARMA PTY LTD (AU) | 2017-02-16 | — | — | WO | disclosed |
| WO-2014063199-A1 | ORGANIC COMPOUNDS | AKAAL PHARMA PTY LTD (AU) | 2014-05-01 | — | — | WO | disclosed |
| WO-2014063199-A1 | ORGANIC COMPOUNDS | AKAAL PHARMA PTY LTD (AU) | 2014-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160038455-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | S1PR1, S1PR5, S1PR2 | S1PR1 1/4885S1PR3 4/4885SMN1; SMN2 3064/4885 |
| US-20110318388-A1 | S1P Receptors Modulators and Their Use Thereof | S1PR1, S1PR5, S1PR2 | S1PR1 1/4885S1PR3 4/4885SMN1; SMN2 3064/4885 |
| US-20140066427-A1 | S1P Receptors Modulators and Their Use Thereof | S1PR1, S1PR2, S1PR5 | S1PR1 1/4885S1PR3 4/4885SMN1; SMN2 2073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.