Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 11/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL28626712 | 0.96 | SLC7A5 (0.48) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL4612310 | 0.96 | SLC7A5 (0.48) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL27683457 | 0.96 | SLC7A5 (0.48) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL3044968 | 0.96 | SLC7A5 (0.48) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL15676202 | 0.93 | SLC7A5 (0.45) | SLC7A5ITGA4ITGB1DPP4CTSC | |
| Tyrosine SCHEMBL12497090 | 0.93 | SLC7A5 (0.51) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL12497096 | 0.93 | SLC7A5 (0.51) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL17728294 | 0.93 | SLC7A5 (0.51) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL6665573 | 0.92 | SLC7A5 (0.56) | SLC7A5ITGA4ITGB1PTGS1ALPI | |
| Tyrosine SCHEMBL4205061 | 0.92 | SLC7A5 (0.61) | SLC7A5ITGA4ITGB1PTGS1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102665749-B | Oral anti-inflammatory agent and oral anti-inflammatory peptide | FUJI OIL CO LTD | 2014-09-17 | — | — | CN | disclosed |
| CN-102665749-A | Oral anti-inflammatory agent and oral anti-inflammatory peptide | FUJI OIL CO LTD | 2012-09-12 | — | — | CN | disclosed |
| US-20120157395-A1 | ANTI-INFLAMMATORY AGENT FOR ORAL APPLICATION, AND ANTI-INFLAMMATORY PEPTIDE FOR ORAL APPLICATION | YOSHINORI MINE (CA) | 2012-06-21 | — | — | US | disclosed |
| US-20120157395-A1 | ANTI-INFLAMMATORY AGENT FOR ORAL APPLICATION, AND ANTI-INFLAMMATORY PEPTIDE FOR ORAL APPLICATION | YOSHINORI MINE (CA) | 2012-06-21 | — | — | US | disclosed |
| WO-2011007612-A1 | ANTI-INFLAMMATORY AGENT FOR ORAL APPLICATION, AND ANTI-INFLAMMATORY PEPTIDE FOR ORAL APPLICATION | 不二製油株式会社 (JP) | 2011-01-20 | — | — | WO | disclosed |