Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | PCNA | P12004 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL1826640 | 0.97 | SLC7A5 (0.52) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL4205061 | 0.95 | SLC7A5 (0.61) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL5152642 | 0.95 | SLC7A5 (0.61) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL4352800 | 0.95 | SLC7A5 (0.61) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL4205059 | 0.95 | SLC7A5 (0.61) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL2205278 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL999871 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL28603345 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL28209802 | 0.92 | SLC7A5 (0.52) | SLC7A5ITGA4PTGS1ALPIPKM | |
| Tyrosine SCHEMBL6545336 | 0.92 | SLC7A5 (0.47) | SLC7A5ITGA4PTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009032-A2 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING HEPATITIS B INFECTION AND SYMPTOMS THEREOF | MYRIAD GENETICS, INC (US) | 2004-01-29 | — | — | WO | disclosed |