Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.38 |
| ▸ | KLK3 | P07288 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318706 | 0.95 | KMT2A (0.47) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL9999132 | 0.91 | MEN1 (0.46) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL319313 | 0.85 | MEN1 (0.46) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL18601789 | 0.85 | MEN1 (0.45) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL318441 | 0.85 | RAB9A (0.46) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL320054 | 0.85 | MEN1 (0.49) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL318592 | 0.84 | KMT2A (0.51) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL318802 | 0.83 | MEN1 (0.44) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL318817 | 0.83 | MEN1 (0.44) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL319002 | 0.82 | MEN1 (0.46) | KMT2AMEN1CYP3A4CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |