Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9998421 | 0.93 | BDKRB2 (0.47) | MEN1CYP3A4CYP2D6KMT2ABDKRB2 | |
| SCHEMBL318308 | 0.86 | NPC1L1 (0.40) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8810961 | 0.84 | MEN1 (0.51) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL11040988 | 0.83 | MEN1 (0.50) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9998323 | 0.82 | MEN1 (0.55) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318845 | 0.82 | OPRL1 (0.49) | MEN1CYP3A4CYP2D6KMT2ABDKRB2 | |
| Trifluoroacetic Acid SCHEMBL8806299 | 0.82 | MEN1 (0.50) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318495 | 0.79 | NPC1L1 (0.45) | MEN1CYP3A4CYP2D6KMT2ABDKRB2 | |
| SCHEMBL319406 | 0.78 | BDKRB2 (0.43) | BDKRB2 | |
| SCHEMBL318803 | 0.76 | MEN1 (0.51) | MEN1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |