Sugi Predict

Sugi Predict / Targets / ACTL6A

ACTL6A

Actin-like protein 6A · O96019 · ACTL6A on Sugi Atlas →

1,607 patent compounds predicted against ACTL6A, 1,403 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Molibresib Molibresib (SCHEMBL1872390) 1.00 1/20
Molibresib Molibresib (SCHEMBL12671490) 1.00 1/20
Molibresib Molibresib (SCHEMBL12966358) 1.00 1/20
SCHEMBL9998851 SCHEMBL9998851 0.91 1/20
SCHEMBL14756282 SCHEMBL14756282 0.88 1/20
SCHEMBL15980874 SCHEMBL15980874 0.88 1/20
SCHEMBL12966165 SCHEMBL12966165 0.87 1/20
SCHEMBL14756215 SCHEMBL14756215 0.87 1/20
SCHEMBL14756339 SCHEMBL14756339 0.87 1/20
SCHEMBL15980861 SCHEMBL15980861 0.87 1/20
SCHEMBL9998825 SCHEMBL9998825 0.86 1/20
SCHEMBL15980893 SCHEMBL15980893 0.86 1/20
SCHEMBL15980803 SCHEMBL15980803 0.86 1/20
SCHEMBL1874116 SCHEMBL1874116 0.85 1/20
SCHEMBL12671221 SCHEMBL12671221 0.85 1/20
SCHEMBL14756021 SCHEMBL14756021 0.85 1/20
SCHEMBL14756240 SCHEMBL14756240 0.85 1/20
SCHEMBL14756287 SCHEMBL14756287 0.85 1/20
SCHEMBL14756335 SCHEMBL14756335 0.85 1/20
SCHEMBL14756409 SCHEMBL14756409 0.85 1/20

Clinical trials — most relevant to ACTL6A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Biologic Correlative Taxotere/AC PHASE2COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability PHASE1COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer nanUNKNOWN
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Family Blood Pressure Program - GenNet Network nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions nanRECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms nanCOMPLETED
GARM II: A Study on the Genetics of Age-related Maculopathy nanACTIVE_NOT_RECRUITING
Markers and Mechanisms of Macrovascular Disease in IDDM nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma nanCOMPLETED
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism nanCOMPLETED
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
The Synergistic Effects of AIH and FES in Persons With MS nanACTIVE_NOT_RECRUITING
Gene Analysis of Parkinson's Disease nanCOMPLETED
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome nanRECRUITING
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS) nanRECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome nanCOMPLETED
Evaluation of Limb-Girdle Muscular Dystrophy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ACTL6A binder may also engage these)

ProteinNameSimilarity
Q9Z2N8 — 1.000 Q9Z2N8 →
Q4R333 — 1.000 Q4R333 →
O94805 — 1.000 O94805 →
P86173 — 0.999 P86173 →
Q99MR0 — 0.996 Q99MR0 →
A4FUX8 — 0.996 A4FUX8 →
A2XMK6 — 0.991 A2XMK6 →
A3ANB5 — 0.991 A3ANB5 →
Q8L4Y5 — 0.984 Q8L4Y5 →
Q9P7X7 — 0.982 Q9P7X7 →
Q5NBI2 — 0.981 Q5NBI2 →
P45890 — 0.981 P45890 →
P47117 — 0.980 P47117 →
A2WNB0 — 0.978 A2WNB0 →
Q09443 — 0.978 Q09443 →
Q54I79 — 0.978 Q54I79 →
Q6C061 — 0.976 Q6C061 →
Q6C982 — 0.976 Q6C982 →
Q5AW89 — 0.975 Q5AW89 →
Q09849 — 0.975 Q09849 →
Q7SHR0 — 0.975 Q7SHR0 →
Q0IEG8 — 0.974 Q0IEG8 →
Q8LGE3 — 0.973 Q8LGE3 →
P38696 — 0.973 P38696 →
P12715 — 0.973 P12715 →
P25840 — 0.973 P25840 →
Q61JZ2 — 0.972 Q61JZ2 →
P07828 — 0.972 P07828 →
P02583 — 0.971 P02583 →
Q93132 — 0.971 Q93132 →