Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.85 |
| ▸ | BRD2 | P25440 | 2/20 | 0.85 |
| ▸ | SMCHD1 | A6NHR9 | 1/20 | 0.85 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.85 |
| ▸ | AIP | O00170 | 1/20 | 0.85 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.85 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.85 |
| ▸ | CDC7 | O00311 | 1/20 | 0.85 |
| ▸ | SAP18 | O00422 | 1/20 | 0.85 |
| ▸ | KPNA3 | O00505 | 1/20 | 0.85 |
| ▸ | PPP6C | O00743 | 1/20 | 0.85 |
| ▸ | TCERG1 | O14776 | 1/20 | 0.85 |
| ▸ | UBE2L6 | O14933 | 1/20 | 0.85 |
| ▸ | PPP1R12A | O14974 | 1/20 | 0.85 |
| ▸ | U2SURP | O15042 | 1/20 | 0.85 |
| ▸ | SETD1A | O15047 | 1/20 | 0.85 |
| ▸ | ARPC1B | O15143 | 1/20 | 0.85 |
| ▸ | POLR1C | O15160 | 1/20 | 0.85 |
| ▸ | OGT | O15294 | 1/20 | 0.85 |
| ▸ | PPM1G | O15355 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12671221 | 1.00 | BRD4 (0.85) | BRD4BRD2SMCHD1MYO1GAIP | |
| Trifluoroacetic Acid SCHEMBL12804010 | 0.95 | BRD4 (0.78) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL25215661 | 0.95 | BRD4 (0.85) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL15980892 | 0.95 | BRD4 (0.85) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL14756335 | 0.95 | BRD4 (0.85) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL14756293 | 0.94 | BRD4 (0.83) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL15980893 | 0.94 | BRD4 (0.86) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL15970073 | 0.94 | BRD4 (0.83) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL15981844 | 0.94 | BRD4 (0.83) | BRD4BRD2SMCHD1MYO1GAIP | |
| SCHEMBL14756327 | 0.94 | BRD4 (0.83) | BRD4BRD2SMCHD1MYO1GAIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170145021-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE LLC | 2017-05-25 | — | — | US | disclosed |
| US-9598420-B2 | Benzodiazepine bromodomain inhibitor | GLAXOSMITHKLINE LLC (US) | 2017-03-21 | — | — | US | disclosed |
| EP-3050885-A1 | BENZODIAZEPINE BROMODOMAIN INHIBITOR | Glaxosmithkline LLC (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2496582-B1 | BENZODIAZEPINE BROMODOMAIN INHIBITOR | GLAXOSMITHKLINE LLC (US) | 2016-01-27 | — | — | EP | disclosed |
| US-20150299210-A1 | Benzodiazepine Bromodomain Inhibitor | GLAXOSMITHKLINE LLC | 2015-10-22 | — | — | US | disclosed |
| US-9102677-B2 | Benzodiazepine bromodomain inhibitor | GLAXOSMITHKLINE LLC (US) | 2015-08-11 | — | — | US | disclosed |
| US-20120252781-A1 | Benzodiazepine Bromodomain Inhibitor | GLAXOSMITHKLINE LLC | 2012-10-04 | — | — | US | disclosed |
| US-20120252781-A1 | Benzodiazepine Bromodomain Inhibitor | GLAXOSMITHKLINE LLC | 2012-10-04 | — | — | US | disclosed |
| EP-2496582-A1 | BENZODIAZEPINE BROMODOMAIN INHIBITOR | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054845-A1 | BENZODIAZEPINE BROMODOMAIN INHIBITOR | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299210-A1 | Benzodiazepine Bromodomain Inhibitor | GABRB1, GABRB3, GABRB2 | BRD4 4/4885BRD2 18/4885SMCHD1 3925/4885 |
| US-20170145021-A1 | NOVEL COMPOUNDS | GABRE, GABRA1, GABRA6 | BRD4 642/4885BRD2 1190/4885SMCHD1 4844/4885 |
| US-20120252781-A1 | Benzodiazepine Bromodomain Inhibitor | GABRB1, GABRB3, GABRB2 | BRD4 4/4885BRD2 18/4885SMCHD1 3925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.