Sugi Predict

Sugi Predict / Targets / ADAMTS12

ADAMTS12

A disintegrin and metalloproteinase with thrombospondin motifs 12 · P58397 · ADAMTS12 on Sugi Atlas →

308 patent compounds predicted against ADAMTS12, 291 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL24927910 SCHEMBL24927910 1.00 1/20
SCHEMBL23371241 SCHEMBL23371241 0.82 1/20
SCHEMBL23354011 SCHEMBL23354011 0.78 1/20
SCHEMBL29979901 SCHEMBL29979901 0.78 1/20
SCHEMBL23354379 SCHEMBL23354379 0.76 1/20
SCHEMBL23371371 SCHEMBL23371371 0.76 1/20
SCHEMBL31676800 SCHEMBL31676800 0.76 1/20
SCHEMBL24927895 SCHEMBL24927895 0.75 1/20
SCHEMBL23354362 SCHEMBL23354362 0.74 1/20
SCHEMBL31676798 SCHEMBL31676798 0.74 1/20
SCHEMBL24928063 SCHEMBL24928063 0.73 1/20
SCHEMBL24927755 SCHEMBL24927755 0.72 1/20
SCHEMBL29979260 SCHEMBL29979260 0.72 1/20
SCHEMBL23354426 SCHEMBL23354426 0.72 1/20
SCHEMBL31676856 SCHEMBL31676856 0.72 1/20
SCHEMBL23354205 SCHEMBL23354205 0.72 1/20
SCHEMBL23354311 SCHEMBL23354311 0.72 1/20
SCHEMBL24928402 SCHEMBL24928402 0.72 1/20
SCHEMBL29979077 SCHEMBL29979077 0.72 1/20
SCHEMBL29979293 SCHEMBL29979293 0.72 1/20

Clinical trials — most relevant to ADAMTS12 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura PHASE4WITHDRAWN
Aspirin for Prophylaxis of TTP PHASE2/PHASE3NOT_YET_RECRUITING
PRP in ACLR to Prevent PTOA PHASE3RECRUITING
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura PHASE3ACTIVE_NOT_RECRUITING
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP) PHASE2COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast PHASE2COMPLETED
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint PHASE2COMPLETED
Modified CV Regimen in Optic Pathway Glioma PHASE2RECRUITING
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP) PHASE1COMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO) nanUNKNOWN
A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI) nanUNKNOWN
ADAMTS13 in Thrombotic Thrombocytopenic Purpura nanCOMPLETED
Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic Purpura nanACTIVE_NOT_RECRUITING
Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome) nanRECRUITING
A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI) nanUNKNOWN
TTP and aHUS in Complicated Pregnancies nanUNKNOWN
Expanded Access Program of TAK-755 for Congenital Thrombotic Thrombocytopenic Purpura (cTTP) nanAPPROVED_FOR_MARKETING
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia nanUNKNOWN
A Study to Learn More About the Treatment of People With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Who Received Recombinant ADAMTS13 (rADAMTS13) as Part of the Early Access Program nanNOT_YET_RECRUITING
Screening of TMA Patients für ADAMTS13 Activity (Adamscreen) nanUNKNOWN
A Survey of Recombinant ADAMTS13 in Participants With Congenital Thrombotic Thrombocytopenic Purpura nanRECRUITING
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial nanCOMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects nanAVAILABLE
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer nanCOMPLETED
Apoptotic Changes in Gingiva Caused by Smoking nanCOMPLETED
The United Kingdom Thrombotic Thrombocytopenic Purpura Registry (UK TTP Registry) nanUNKNOWN
Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock nanCOMPLETED
LRP1 and Colon Cancer nanUNKNOWN
Italian iTTP Registry nanRECRUITING
Prognostic Indices of Atheromatosis Severity and Coronary Artery Bypass Surgery Outcomes for Patients With Coronary Artery Disease nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADAMTS12 binder may also engage these)

ProteinNameSimilarity
Q811B3 — 1.000 Q811B3 →
P59510 — 0.998 P59510 →
Q9UKP5 — 0.995 Q9UKP5 →
ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 0.994 landscape →
Q1EHB3 — 0.993 Q1EHB3 →
Q68SA9 — 0.993 Q68SA9 →
Q19791 — 0.990 Q19791 →
P97857 — 0.990 P97857 →
P58459 — 0.990 P58459 →
Q8WXS8 — 0.990 Q8WXS8 →
Q9H324 — 0.990 Q9H324 →
Q9UKF2 — 0.990 Q9UKF2 →
P59384 — 0.990 P59384 →
Q28475 — 0.990 Q28475 →
E9NW27 — 0.989 E9NW27 →
Q5R544 — 0.989 Q5R544 →
O15072 — 0.989 O15072 →
P59511 — 0.989 P59511 →
O77633 — 0.988 O77633 →
Q63202 — 0.988 Q63202 →
Q8N6G6 — 0.988 Q8N6G6 →
Q9WUQ1 — 0.987 Q9WUQ1 →
Q8TE58 — 0.987 Q8TE58 →
Q9H2U9 — 0.987 Q9H2U9 →
P82987 — 0.987 P82987 →
Q69Z28 — 0.987 Q69Z28 →
Q90YA6 — 0.987 Q90YA6 →
Q5R1W3 — 0.987 Q5R1W3 →
G5ECS8 — 0.986 G5ECS8 →
A3R0T9 — 0.986 A3R0T9 →