ADAMTS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6595826	1.00	3/20
SCHEMBL6597239	1.00	3/20
SCHEMBL6597486	1.00	3/20
SCHEMBL6598045	0.94	3/20
SCHEMBL6592990	0.92	3/20
SCHEMBL6595882	0.92	3/20
SCHEMBL6598340	0.92	3/20
SCHEMBL6596298	0.91	3/20
SCHEMBL6595027	0.85	3/20
SCHEMBL6593623	0.85	3/20
SCHEMBL6594437	0.85	3/20
SCHEMBL6597075	0.84	3/20
SCHEMBL6597320	0.84	3/20
SCHEMBL6597759	0.84	3/20
SCHEMBL6593683	0.84	3/20
Trifluoroacetic Acid (SCHEMBL6594200)	0.84	3/20
Trifluoroacetic Acid (SCHEMBL6594386)	0.84	3/20
SCHEMBL6594466	0.83	3/20
SCHEMBL6595469	0.83	3/20
SCHEMBL6595495	0.83	3/20

Clinical trials — most relevant to ADAMTS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura	PHASE4	WITHDRAWN
Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus.	PHASE4	COMPLETED
Aspirin for Prophylaxis of TTP	PHASE2/PHASE3	NOT_YET_RECRUITING
PRP in ACLR to Prevent PTOA	PHASE3	RECRUITING
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)	PHASE2	COMPLETED
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint	PHASE2	COMPLETED
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP)	PHASE1	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO)	nan	UNKNOWN
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia	nan	UNKNOWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Exercise-related Irisin on Inflammation and Pain	nan	UNKNOWN
A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI)	nan	UNKNOWN
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
ADAMTS13 in Thrombotic Thrombocytopenic Purpura	nan	COMPLETED
LRP1 and Colon Cancer	nan	UNKNOWN
Peri-implantitis and MMP-8	nan	COMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Screening of TMA Patients für ADAMTS13 Activity (Adamscreen)	nan	UNKNOWN
TTP and aHUS in Complicated Pregnancies	nan	UNKNOWN
Matrix Metalloproteinases 7 and 9 in Rheumatoid Arthritis Patients With Interstitial Lung Disease	nan	NOT_YET_RECRUITING
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Biomarkers in Post Thrombotic Syndrome	nan	COMPLETED
Elevated Plasma Levels of TIMP-1 in Patients With Rotator Cuff Tear	nan	COMPLETED
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia	nan	UNKNOWN
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADAMTS1 binder may also engage these)

Protein	Name	Similarity
P97857	—	1.000	P97857 →
ADAMTS5	A disintegrin and metalloproteinase with thrombospondin motifs 5	1.000	landscape →
Q9WUQ1	—	1.000	Q9WUQ1 →
Q8WXS8	—	1.000	Q8WXS8 →
Q8TE58	—	0.999	Q8TE58 →
Q9H324	—	0.997	Q9H324 →
P59511	—	0.997	P59511 →
P58459	—	0.996	P58459 →
Q69Z28	—	0.996	Q69Z28 →
Q4VC17	—	0.995	Q4VC17 →
Q8TE57	—	0.994	Q8TE57 →
Q8TE60	—	0.993	Q8TE60 →
O95450	—	0.993	O95450 →
P59510	—	0.993	P59510 →
ADAMTS12	A disintegrin and metalloproteinase with thrombospondin motifs 12	0.992	landscape →
Q9UKP5	—	0.992	Q9UKP5 →
Q1EHB3	—	0.992	Q1EHB3 →
Q9ESP7	—	0.992	Q9ESP7 →
ADAMTS7	A disintegrin and metalloproteinase with thrombospondin motifs 7	0.992	landscape →
Q9P2N4	—	0.992	Q9P2N4 →
Q9R001	—	0.991	Q9R001 →
Q9TT93	—	0.991	Q9TT93 →
P59384	—	0.991	P59384 →
Q8C9W3	—	0.991	Q8C9W3 →
O15072	—	0.991	O15072 →
Q19791	—	0.990	Q19791 →
P79331	—	0.990	P79331 →
Q811B3	—	0.989	Q811B3 →
P19336	—	0.987	P19336 →
Q9UKF2	—	0.987	Q9UKF2 →