ADCK1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
R-406 (SCHEMBL1200144)	1.00	2/20
Fostamatinib (SCHEMBL1201371)	1.00	2/20
SCHEMBL2627479	0.92	2/20
SCHEMBL2627469	0.91	2/20
SCHEMBL1383686	0.89	2/20
SCHEMBL2627484	0.84	2/20
R-406 (SCHEMBL1222514)	0.83	2/20
SCHEMBL2627481	0.82	2/20
SCHEMBL2627480	0.76	2/20
SCHEMBL2627470	0.75	2/20
SCHEMBL2627048	0.72	2/20
SCHEMBL2526082	0.72	2/20
SCHEMBL2526159	0.72	2/20
SCHEMBL2523179	0.70	2/20
SCHEMBL2536722	0.69	2/20
SCHEMBL2544982	0.69	2/20
SCHEMBL2525389	0.68	2/20
SCHEMBL2535479	0.68	2/20
SCHEMBL2547766	0.67	2/20
SCHEMBL1380946	0.67	2/20

Clinical trials — most relevant to ADCK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Weight Loss Study: Genetics and Response to Naltrexone/Bupropion	PHASE4	RECRUITING
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)	PHASE4	RECRUITING
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers	PHASE1/PHASE2	NOT_YET_RECRUITING
Safety and Feasibility of Metformin for Sepsis Induced AKI	PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Expression of AMP-activated Protein Kinase (AMPK) Protein in Lung Adenocarcinoma	nan	UNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States	nan	COMPLETED
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Normal Serum Adiponectin Levels in Females	nan	UNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia	nan	RECRUITING
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Rostock International Parkinson's Disease Study (ROPAD)	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADCK1 binder may also engage these)

Protein	Name	Similarity
Q9D0L4	—	1.000	Q9D0L4 →
Q5ZMT7	—	0.992	Q5ZMT7 →
Q5M7P6	—	0.982	Q5M7P6 →
Q6INL7	—	0.974	Q6INL7 →
O04212	—	0.961	O04212 →
GLS2	Glutaminase liver isoform, mitochondrial	0.957	landscape →
P28492	—	0.949	P28492 →
Q9ER35	—	0.948	Q9ER35 →
Q571F8	—	0.947	Q571F8 →
Q9D020	—	0.947	Q9D020 →
Q4R3Y4	—	0.946	Q4R3Y4 →
ZMPSTE24	CAAX prenyl protease 1 homolog	0.946	landscape →
B4G0F3	—	0.946	B4G0F3 →
Q9H0P0	—	0.945	Q9H0P0 →
Q7Z695	—	0.945	Q7Z695 →
ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.945	landscape →
Q7SYN4	—	0.944	Q7SYN4 →
Q6P1M0	—	0.943	Q6P1M0 →
O43272	—	0.943	O43272 →
Q5RFI8	—	0.943	Q5RFI8 →
P52649	—	0.942	P52649 →
Q64323	—	0.942	Q64323 →
Q8R4N0	—	0.942	Q8R4N0 →
D3ZLY0	—	0.942	D3ZLY0 →
Q9JID6	—	0.942	Q9JID6 →
ALG1	Chitobiosyldiphosphodolichol beta-mannosyltransferase	0.942	landscape →
P18163	—	0.942	P18163 →
Q80W54	—	0.942	Q80W54 →
F4JJJ3	—	0.941	F4JJJ3 →
Q6AY30	—	0.941	Q6AY30 →