ADCY9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2657749	0.81	8/20
SCHEMBL2658721	0.74	8/20
SCHEMBL2658383	0.63	8/20
SCHEMBL2657546	0.61	8/20
SCHEMBL2657983	0.60	8/20
SCHEMBL2657082	0.74	7/20
SCHEMBL2657077	0.60	7/20
SCHEMBL1919194	0.53	7/20
SCHEMBL2653753	0.51	7/20
SCHEMBL2654576	0.51	7/20
SCHEMBL2655409	0.51	7/20
SCHEMBL2655997	0.49	7/20
SCHEMBL2656673	0.49	7/20
SCHEMBL2657984	0.64	6/20
SCHEMBL2658531	0.60	6/20
SCHEMBL2653428	0.58	6/20
SCHEMBL2653879	0.57	6/20
SCHEMBL2657305	0.52	6/20
SCHEMBL2656182	0.52	6/20
SCHEMBL2658725	0.51	6/20

Clinical trials — most relevant to ADCY9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Switching of Sildenafil to Riociguat in CTEPH Patients	PHASE4	RECRUITING
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia	PHASE2/PHASE3	UNKNOWN
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm	PHASE2	WITHDRAWN
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies	nan	COMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
Natural History of Spinocerebellar Ataxia Type 7 (SCA7)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADCY9 binder may also engage these)

Protein	Name	Similarity
Q9DGG6	—	1.000	Q9DGG6 →
P51830	—	1.000	P51830 →
P98999	—	1.000	P98999 →
Q9VW60	—	0.991	Q9VW60 →
Q9UPV7	—	0.990	Q9UPV7 →
P40146	—	0.990	P40146 →
P84309	—	0.989	P84309 →
F5HB62	—	0.989	F5HB62 →
Q9NZS9	—	0.989	Q9NZS9 →
Q5PQN2	—	0.989	Q5PQN2 →
Q5VVW2	—	0.989	Q5VVW2 →
P60571	—	0.989	P60571 →
Q580W5	—	0.988	Q580W5 →
Q41607	—	0.988	Q41607 →
A3KMV1	—	0.988	A3KMV1 →
P03177	—	0.988	P03177 →
Q8TBC3	—	0.988	Q8TBC3 →
Q04400	—	0.988	Q04400 →
Q23652	—	0.988	Q23652 →
Q6DK85	—	0.988	Q6DK85 →
P0C7U3	—	0.988	P0C7U3 →
ADCY6	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP py	0.988	landscape →
G5ED39	—	0.988	G5ED39 →
P40144	—	0.987	P40144 →
ADCY5	Adenylate cyclase type 5	0.987	landscape →
O94349	—	0.987	O94349 →
P30645	—	0.987	P30645 →
A2A3K4	—	0.987	A2A3K4 →
A4H7G5	—	0.987	A4H7G5 →
F4J8D3	—	0.987	F4J8D3 →