ADSL — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to ADSL by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
Folate Rechallenge	PHASE2	COMPLETED
A Phase I/II Open-label Safety and Efficacy Study of LNP.UCD.ABE in Patients With Urea Cycle Disorders.	PHASE1/PHASE2	NOT_YET_RECRUITING
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate	PHASE2	WITHDRAWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis	PHASE2	COMPLETED
A Phase 1b Study of Adenylosuccinic Acid (ASA-001) for Adenylosuccinate Synthase 1 (ADSS1) Deficient Myopathy.	PHASE1	ENROLLING_BY_INVITATION
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Anaplerotic Therapy in Propionic Acidemia	PHASE1	COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Androgens and NAFLD Longitudinal Cohort Study	nan	RECRUITING
Clinical and Laboratory Study of Methylmalonic Acidemia	nan	RECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
PCORI Urea Cycle Disorder Study	nan	COMPLETED
Pyridoxine Effect on the Blood Glucose Level in Type 2 Diabetic Patients	nan	COMPLETED
TS Overexpression in SCLC: Mechanism and Therapeutic Targeting	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Role of Genetic Factors in the Development of Lung Disease	nan	RECRUITING
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADSL binder may also engage these)

Protein	Name	Similarity
Q8HXY5	—	1.000	Q8HXY5 →
A3KN12	—	0.999	A3KN12 →
P21265	—	0.997	P21265 →
P54822	—	0.997	P54822 →
Q6IA69	—	0.935	Q6IA69 →
Q4R5Y2	—	0.932	Q4R5Y2 →
Q3ZBF0	—	0.928	Q3ZBF0 →
P61922	—	0.927	P61922 →
Q9H2P9	—	0.924	Q9H2P9 →
Q9Z244	—	0.922	Q9Z244 →
Q9CZX0	—	0.922	Q9CZX0 →
Q9DCZ1	—	0.921	Q9DCZ1 →
ABAT	4-aminobutyrate aminotransferase, mitochondrial	0.920	landscape →
Q9BGI0	—	0.920	Q9BGI0 →
P80147	—	0.920	P80147 →
P36959	—	0.919	P36959 →
Q4R5J0	—	0.919	Q4R5J0 →
Q9VQZ6	—	0.918	Q9VQZ6 →
Q41141	—	0.918	Q41141 →
GNPDA1	Glucosamine-6-phosphate deaminase 1	0.917	landscape →
P38024	—	0.916	P38024 →
P50554	—	0.916	P50554 →
Q7ZV22	—	0.916	Q7ZV22 →
Q3ZBH0	—	0.916	Q3ZBH0 →
CCT8	T-complex protein 1 subunit theta	0.915	landscape →
Q5RAP1	—	0.915	Q5RAP1 →
Q5ZMA6	—	0.915	Q5ZMA6 →
P80314	—	0.915	P80314 →
Q3ZCI9	—	0.915	Q3ZCI9 →
Q8W4M5	—	0.915	Q8W4M5 →