AFG3L2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15569377	0.52	1/20
SCHEMBL15978916	0.45	1/20
SCHEMBL4935060	0.43	1/20
SCHEMBL4935071	0.43	1/20
SCHEMBL29846007	0.41	1/20

Clinical trials — most relevant to AFG3L2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant	PHASE1/PHASE2	RECRUITING
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease	nan	RECRUITING
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality	nan	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Defining the Genetic Etiology of Alzheimer's Disease in the Faroe Islands	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis	nan	UNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a AFG3L2 binder may also engage these)

Protein	Name	Similarity
Q8JZQ2	—	1.000	Q8JZQ2 →
Q2KJI7	—	1.000	Q2KJI7 →
Q920A7	—	1.000	Q920A7 →
Q9UQ90	—	1.000	Q9UQ90 →
Q0DHL4	—	0.998	Q0DHL4 →
Q7TT47	—	0.997	Q7TT47 →
Q9HGM3	—	0.997	Q9HGM3 →
P0A4V9	—	0.997	P0A4V9 →
A5U8T5	—	0.997	A5U8T5 →
Q84WU8	—	0.997	Q84WU8 →
Q3ULF4	—	0.996	Q3ULF4 →
Q9N3T5	—	0.996	Q9N3T5 →
Q1D491	—	0.995	Q1D491 →
P9WQN2	—	0.995	P9WQN2 →
Q39102	—	0.995	Q39102 →
Q925S8	—	0.994	Q925S8 →
Q9BAE0	—	0.994	Q9BAE0 →
P39925	—	0.994	P39925 →
P9WQN3	—	0.994	P9WQN3 →
Q8W585	—	0.993	Q8W585 →
B3DY14	—	0.993	B3DY14 →
Q8VZI8	—	0.993	Q8VZI8 →
Q1PDW5	—	0.993	Q1PDW5 →
P51327	—	0.993	P51327 →
P40341	—	0.993	P40341 →
Q8LQJ9	—	0.993	Q8LQJ9 →
Q10ZF7	—	0.993	Q10ZF7 →
C8WEG0	—	0.993	C8WEG0 →
B4SCV5	—	0.992	B4SCV5 →
O78516	—	0.992	O78516 →