AK1

Adenylate kinase isoenzyme 1 · P00568 · AK1 on Sugi Atlas →

0 patent compounds predicted against AK1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to AK1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS) PHASE4RECRUITING
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Safety and Feasibility of Metformin for Sepsis Induced AKI PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Bempedoic Acid Therapy for Polycystic Kidney Disease PHASE2NOT_YET_RECRUITING
A Study of AK146D1 for Injection in the Treatment of Advanced Solid Tumors PHASE1RECRUITING
A Study of AK146D1 for Injection in Advanced Solid Tumors PHASE1RECRUITING
A Phase I Study of AK138D1 in the Treatment of Advanced Solid Tumors PHASE1RECRUITING
A Study of AK119 (Anti-CD73) in Combination With AK104 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
A Study of AK138D1 in Advanced Malignant Tumors PHASE1RECRUITING
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus PHASE1COMPLETED
A Study to Evaluate the Efficacy and Safety of AK127 in Patients With Advanced Solid Tumors PHASE1UNKNOWN
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK127 in Combination With AK104 in Advanced and Metastatic Solid Tumours EARLY_PHASE1COMPLETED
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole nanWITHDRAWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Expression of AMP-activated Protein Kinase (AMPK) Protein in Lung Adenocarcinoma nanUNKNOWN
Assessment of Serum Magnesium Level with Diabetic Foot Ulceration in Type II Diabetes Associated with Diabetic Nephropathy Patients nanNOT_YET_RECRUITING
The Use of AKR1B10 for Monitoring Postoperative Recurrence of Hepatocellular Carcinoma nanNOT_YET_RECRUITING
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome nanCOMPLETED
The Effect of White Tea Consumption on Obesity nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a AK1 binder may also engage these)

ProteinNameSimilarity
P00570 1.000 P00570 →
P00571 1.000 P00571 →
P00569 0.999 P00569 →
Q9R0Y5 0.997 Q9R0Y5 →
P39069 0.994 P39069 →
P05081 0.993 P05081 →
Q20140 0.979 Q20140 →
P12115 0.979 P12115 →
O04905 0.971 O04905 →
P43188 0.966 P43188 →
Q7XI40 0.964 Q7XI40 →
Q6K7H2 0.962 Q6K7H2 →
G4V9S0 0.958 G4V9S0 →
P25824 0.956 P25824 →
Q5RDZ0 0.949 Q5RDZ0 →
Q9UIJ7 0.946 Q9UIJ7 →
Q9WTP7 0.944 Q9WTP7 →
Q5R421 0.944 Q5R421 →
Q7ZWE9 0.942 Q7ZWE9 →
Q9WUR9 0.942 Q9WUR9 →
P27144 0.941 P27144 →
P29411 0.941 P29411 →
Q64520 0.941 Q64520 →
C4ZUS8 0.940 C4ZUS8 →
B7L799 0.940 B7L799 →
B1IZC0 0.940 B1IZC0 →
A4SLY1 0.940 A4SLY1 →
Q83M40 0.939 Q83M40 →
HMBS Porphobilinogen deaminase 0.939 landscape →
Q29554 0.939 Q29554 →